August 27, 2021

HIV/AIDS research

Kaiser Permanente is among the largest providers of HIV care in the U.S. Our research has informed policy and practice and helped people live longer, healthier lives.

This brief summarizes the contributions of Kaiser Permanente Research since 2007 on the topic of HIV and AIDS.

Since the height of the HIV and AIDS epidemic in the mid-1980s, the number of new HIV infections occurring each year in the United States has fallen by more than two-thirds.1 Nevertheless, according to the Centers for Disease Control and Prevention, approximately 40,000 new cases of HIV are diagnosed each year in the United States, and just over 18,000 people received a diagnosis of AIDS in 2016.2,3 Further, the CDC estimates that 13% of people living with HIV are unaware of their infection. Two-thirds of new HIV diagnoses occur in men who have sex with men.3 Moreover, despite representing just 30% of the U.S. population, nearly 2 out of 3 new HIV infections occur in Black and Latino Americans.3

Because of treatment advances and improved survival that began in the late 1990s, the number of Americans living with HIV has increased substantially.1 By the end of 2015, an estimated 1.1 million adolescents and adults were living with HIV.2 Among those living with HIV, nearly two-thirds were receiving treatment for the disease, and approximately half had achieved viral suppression.4 People who sustain viral suppression can remain healthy and have almost no risk of sexually transmitting HIV to uninfected partners. The risk of transmission has been further reduced through interventions such as pre-exposure prophylaxis, or PrEP, which is a prescription of HIV antiviral drugs that helps prevent infection in people without HIV.

Publications related to HIV/AIDS since 2007

749 Journal Articles, 40K Citations (a), 184 Practice Guideline References (b), 83 Clinical Decision Aid References (c)

Source: Kaiser Permanente Publications Library and PLUM metrics, as of October 19, 2020.

a. Number of citing journal articles, according to Scopus.
b. Number of references in PubMed guidelines.
c. Citations in DynaMed Plus, a point-of-care clinical reference tool.

HIV/AIDS is an active area of study for Kaiser Permanente Research. Scientists across the program have used our rich and comprehensive longitudinal data to advance knowledge in the areas of understanding risk, improving patient outcomes, and translating research findings into policy and practice. We have published more than 650 articles related to HIV and AIDS since 2007, which have been cited nearly 45,000 times.5 These articles are the product of observational studies, randomized controlled trials, meta-analyses, and other studies led by Kaiser Permanente scientists. Our unique environment — a fully integrated care and coverage model in which our research scientists, clinicians, medical groups, and health plan leaders collaborate — lets us contribute generalizable knowledge on HIV/AIDS, and many other topics of research.



  1. Centers for Disease Control and Prevention. CDC Fact Sheet: Today’s HIV/AIDS Epidemic. Atlanta, GA: Author; 2016.
  2. Centers for Disease Control and Prevention. Estimated HIV incidence and prevalence in the United States, 2010–2015. HIV Surveillance Supplemental Report 2018. Atlanta, GA: Author; 2018.
  3. Centers for Disease Control and Prevention. HIV Surveillance Report, 2016. Atlanta, GA: Author; 2017.
  4. Centers for Disease Control and Prevention. Monitoring selected national HIV prevention and care objectives by using HIV surveillance data — United States and 6 dependent areas, 2015. HIV Surveillance Supplemental Report 2017. Atlanta, GA: Author; 2017. 
  5. KPPL Search, conducted on July 24, 2019: (dc.title:HIV OR dc.title:” human immunodeficiency virus” OR dc.title:AIDS OR dc.subject.mesh:” Acquired Immunodeficiency Syndrome” OR dc.subject.mesh:”Acquired Immunodeficiency Syndrome/”* OR dc.subject.mesh:”HIV-1” OR dc.subject.mesh:”HIV-1/”* OR dc.subject. mesh:”Sarcoma, Kaposi “ OR dc.subject.mesh:” Anti-HIV Agents “ OR dc.subject.mesh:” Anti-HIV Agents/”* OR dc.subject.mesh:”HIV Infections” OR dc.subject.mesh:” CD4 Lymphocyte Count” OR dc.subject.mesh:HIV OR dc.subject.mesh:”aids-related opportunistic infections”) AND dc.type:”Journal Article” AND issued:[2007 2019].