Kaiser Permanente-led study among largest to evaluate adding MRI surveillance for breast cancer survivors.
SEATTLE — When breast cancer survivors were screened using breast magnetic resonance imaging (MRI), they had more than twice as many biopsies as did those screened using mammography alone and had more breast cancers detected, according to new research published in the journal Radiology. However, the extra screening is not necessarily an improvement over what would have been detected in usual care with mammography, said the authors. In fact, there were no differences between surveillance MRI and mammography in the ability to distinguish breast cancer from other findings (sensitivity) or to rule cancer out (specificity), they explained.
After women complete treatment for breast cancer, guidelines recommend annual mammography to screen for second breast cancers, said study leader Karen Wernli, PhD, an associate investigator at Kaiser Permanente Washington Research Institute and an affiliate associate professor of health services at the University of Washington School of Public Health.
“Our previous research showed that in practice, breast MRI is also being used to screen a growing number of women who have had breast cancer — often between yearly mammograms,” said Wernli. “But more testing isn’t always better.”
Unlike prior studies, this one adjusted for differences between women who only received mammography and women who received breast MRI in addition to mammography. The women who received breast MRI tended to have a more advanced stage of cancer, denser breasts, and diagnosis at a younger age, which can all raise the risk of second cancers. This might be one reason for the slightly higher cancer rate the study found with the addition of breast MRI, Wernli explained. Further, women who had more education and income were also more likely to receive breast MRI — not specifically because they had higher risk of second cancers, but because they likely had more access to resources, she added.
The study engaged stakeholders including patient partners who have had breast cancer. Two of these patients, Dianne Johnson and Mary Bush, are study coauthors. “They helped us stay focused on the real-life experiences behind the numbers,” Dr. Wernli said.
Some women may feel reassured when they have a biopsy that shows no cancer, while others want to avoid unnecessary biopsies. Ms. Johnson said, “As someone who has had breast cancer and has listened to many other women across the country as part of this study, having to get another biopsy after already being treated for cancer raises women’s anxiety and distress until they have the result — but most will endure the stress to be sure about whether the finding is cancer.”
Supplementing mammography with breast MRI is recommended for women at high risk for breast cancer (e.g., with certain mutations and family histories). In 2018, the American College of Radiology recommended yearly breast MRI also for breast cancer survivors who either have dense breasts or had breast cancer diagnosed before age 50. This study focused on the use of breast MRI only in women with prior breast cancer.
“Evidence about breast MRI’s benefits and harms in breast cancer survivors is lacking,” Karla Kerlikowske, MD, a professor of medicine and of epidemiology and biostatistics at the University of California, San Francisco and Veterans Affairs. “This study helps fill that gap. And women with prior breast cancer need to remember to continue with annual mammography.”
This is the largest and most comprehensive study of its kind to date, including more than 13,000 women aged 18 or older diagnosed with stage 0–III breast cancer. They were screened with nearly 34,000 mammograms and more than 2,500 breast MRIs from 2005 to 2012. The study used data from five registries in the Breast Cancer Surveillance Consortium (BCSC): The Carolina Mammography Registry, Kaiser Permanente Washington, New Hampshire Mammography Network, San Francisco Mammography Registry, and Vermont Breast Cancer Surveillance System.
Next, the research team wants to determine whether any subgroups of women who have had breast cancer might benefit more than others from breast MRI surveillance.
Breast cancer is an active area of research at Kaiser Permanente.
Co-authors on the study included Laura Ichikawa, PhD, Diana Buist, PhD, and Susan Brandzel, MPH, of Kaiser Permanente Washington Health Research Institute; Diana Miglioretti, PhD, of Kaiser Permanente Washington Health Research Institute and the University of California, Davis; Janie M. Lee, MD, of the University of Washington and Seattle Cancer Care Alliance, who is also an affiliate investigator at KPWHRI; Louise M. Henderson, PhD, of the University of North Carolina, Chapel Hill; Larissa Nekhlyudov, MD, MPH, of Brigham and Women’s Hospital, in Boston; Tracy Onega, PhD, of Dartmouth Medical School, in Hanover; Brian L. Sprague, PhD, of the University of Vermont, in Burlington; and Constance Lehman, MD, of Massachusetts General Hospital, in Boston.
Patient-Centered Outcomes Research Institute funded this study through award CE-1304-6656. This study was registered at clinicaltrials.gov: NCT02212834.
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